• 名称：JNJ-28312141
• 简介：JNJ-28312141 is an orally active CSF1R inhibitor (Colony-stimulating factor-1 receptor, CRF1R) and also a FLT3 inhibitor. CSF1R is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. JNJ-28312141 represents a new agent with potential therapeutic activity in acute myeloid leukemia and in settings where CSF-1-dependent macrophages and osteoclasts contribute to tumor growth and skeletal events.
• CASNO：885692-52-4
• 分子式：C26H32N6O2
• 分子量：460.57
• SMILES：CN(C)CC(=O)N1CCC(CC1)C2=CC(=C(C=C2)NC(=O)C3=NC=C(N3)C#N)C4=CCCCC4
• 保持条件：at -20°C 3 years Powder
• 同名：JNJ 28312141, JNJ28312141
• 纯度：>98%
• 应用：CSF1R inhibitor
• 作用机制：Inhibitor