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- 名称：PF-5274857
- 简介：PF-5274857 is a novel Smo antagonist that specifically binds to Smo with a K(i) of 4.6 ± 1.1 nmol/L and completely blocks the transcriptional activity of the downstream gene Gli1 with an IC(50) of 2.7 ± 1.4 nmol/L in cells.
- CASNO：1373615-35-0
- 分子式：C20H25ClN4O3S
- 分子量：436.96
- SMILES：CC1=CC(=C(N=C1)C2=CC(=NC=C2Cl)N3CCN(CC3)C(=O)CCS(=O)(=O)C)C
- 保持条件：at -20°C 3 years Powder
- 同名：PF5274857, PF 5274857
- 纯度：>98%
- 应用：Smoothened Inhibitor
- 作用机制：Inhibitor
