• 名称：Afuresertib HCl
• 简介：Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. It binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.
• CASNO：1047645-82-8
• 分子式：C18H18Cl3FN4OS
• 分子量：463.78
• SMILES：CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)NC(CC3=CC(=CC=C3)F)CN)Cl.Cl
• 保持条件：at -20°C 3 years Powder
• 同名：GSK2110183, GSK 2110183
• 纯度：>98%
• 应用：AKT inhibitor?
• 作用机制：Inhibitor