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- 名称：GSK343
- 简介：GSK343 is a potent histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor (IC= 4 nM). Diplays 1000-fold selectivity for other HMTs except EZH1 (60-fold selectivity). GSK343 inhibits H3K27 methylation in HCC1806 cells with an IC of <200nM (measured by immunofluorescence).
- CASNO：1346704-33-3
- 分子式：C31H39N7O2
- 分子量：541.69
- SMILES：CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC(=NC=C4)N5CCN(CC5)C)C(C)C
- 保持条件：at -20°C 3 years Powder
- 同名：GSK-343, GSK 343
- 纯度：>98%
- 应用：EZH2 inhibitor
- 作用机制：Inhibitor
