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PD173955
PD173955
  • 商品货号:A13120
  • 已售 0 件 | 评价 0 人次 | 关注度 1534
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    • 名称:PD173955
    • 简介:PD-173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr-Abl-dependent cell growth. PD173955 showed cell cycle arrest in G(1). PD173955 has an IC(50) of 1-2 nM in kinase inhibition assays of Bcr-Abl, and in cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 inhibited kit ligand-dependent c-kit autophosphorylation (IC(50) = approximately 25 nM) and kit ligand-dependent proliferation of M07e cells (IC(50) = 40 nM) but had a lesser effect on interleukin 3-dependent (IC(50) = 250 nM) or granulocyte macrophage colony-stimulating factor (IC(50) = 1 microM)-dependent cell growth.
    • CASNO:260415-63-2
    • 分子式:C21H16Cl2N4OS
    • 分子量:443.35
    • SMILES:CN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=CC=C3Cl)Cl)NC4=CC(=CC=C4)SC
    • 保持条件:at -20°C 3 years Powder
    • 同名:PD 173955; PD-173955
    • 纯度:>98%
    • 应用:Bcr-Abl inhibitor
    • 作用机制:Inhibitor
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