• 名称：IWP-3
• 简介：IWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC?? = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC?? = 1.2 μM).
• CASNO：687561-60-0
• 分子式：C22H17FN4O2S3
• 分子量：484.59
• SMILES：O=C(CSC(N1C2=CC=C(F)C=C2)=NC3=C(SCC3)C1=O)NC4=NC5=C(C=C(C)C=C5)S4
• 保持条件：at -20°C 3 years Powder
• 同名：IWP 3,IWP3
• 纯度：>98%
• 应用：Wnt inhibitor
• 作用机制：Inhibitor