• 名称：Astemizole
• 简介：Astemizole is a potent antihistamine (H1-receptor antagonist, IC50 = 4 nM) that displays selectivity over dopamine, 5-HT, and muscarinic acetylcholine receptors. This compound has shown potent hERG K+ channel blocking activity (IC50 = 0.9 nM), antimalarial activity in multidrug resistant strains in vitro (IC50 = 227 - 734 nM), and has been used as a chaperone to correct folding defects and restore protein function for some mutated forms of hERG channels.
• CASNO：68844-77-9
• 分子式：C28H31FN4O
• 分子量：458.57
• SMILES：COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F
• 保持条件：at -20°C 3 years Powder
• 同名：Astemisan, Hismanal, Histamen, Paralergim
• 纯度：>98%
• 应用：H1-receptor antagonist
• 作用机制：Antagonist