• 名称：AM 114
• 简介：AM 114, a derivative of boronic chalcone, is a potent small-molecule inhibitor of the proteasome that inhibits the chymotrypsin-like activity of the 20S proteasome, with a value of 50% inhibition concentration IC50 of approximately 1 uM, resulting in a significant accumulation of ubiquitinated p53 and other cellular proteins in whole cells without significantly disrupting the interaction of p53 and murine double minute 2 (mdm2) proteins.
• CASNO：856849-35-9
• 分子式：C20H21B2NO5
• 分子量：377.01
• SMILES：B(C1=CC=C(C=C1)C=C2CN(CC(=CC3=CC=C(C=C3)B(O)O)C2=O)C)(O)O
• 保持条件：at -20°C 3 years Powder
• 同名：N/A
• 纯度：>98%
• 应用：20S proteasome inhibitor
• 作用机制：Inhibitor