• 名称：PIM447 (LGH447)
• 简介：PIM447 is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>105-fold differential relative to the Ki on PIMs).
• CASNO：1210608-43-7
• 分子式：C24H23F3N4O
• 分子量：440.47
• SMILES：O=C(NC1=C([C@H]2C[C@@H](N)C[C@@H](C)C2)C=CN=C1)C3=NC(C4=C(F)C=CC=C4F)=C(F)C=C3
• 保持条件：at -20°C 3 years Powder
• 同名：LGH-447; LGH 447; LGH447; PIM447; PIM-447; PIM 447; LGH447 free base
• 纯度：>98%
• 应用：Pim inhibitor
• 作用机制：Inhibitor