• 商品货号：F158278

• accession：NM_080687
• 基因别名：UPF3A
• 基因描述：Homo sapiens UPF3 regulator of nonsense transcripts homolog A (yeast) (UPF3A), transcript variant 2, mRNA.
• 载体：现货载体
• CDS区长度：1332
• 翻译后氨基酸长度：443
• TranscriptVariant：This variant (2) lacks an in-frame exon in the 5' coding region, compared to transcript variant 1. The resulting isoform (hUpf3pdelta) lacks an internal segment, compared to isoform hUpf3p.
• 基因简介：This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
• 载体信息：自有图片地址
• 规格：10ul 质粒

CDS区参考序列： 点击查看序列

ATGCGCTCGGAAAAGGAGGGGGCCGGAGGCCTTCGGGCGGCCGTTGCCGCGCGGGGCCCGAGCGGGAGGGAGAAGCTGTCGGCCCTAGAAGTGCAGTTCCACCGCGACTCGCAGCAGCAGGAGGCTGAGACGCCGCCAACTTCGTCCTCCGGTTGCGGGGGCGGTGCGGGCAAACCTCGCGAGGAGAAGAGGACGGCCCTGAGCAAGGTGGTCATCCGCCGCCTGCCTCCGGGCCTCACCAAGGAGCAGCTGGAGGAGCAGCTGCGCCCGCTGCCAGCACACGACTACTTCGAGTTCTTCGCCGCCGACCTGAGTCTTTATCCTCATCTCTACTCAAGAGCATACATTAATTTTAGGAATCCTGATGACATCCTTCTTTTTAGAGATCGTTTTGATGGATATATCTTCCTTGACAGCAAAGATCCAGAATATAAGAAGTTTTTAGAAACCTACTGTGTGGAGGAAGAGAAGACCAGTGCCAACCCTGAGACTCTGCTGGGGGAGATGGAGGCGAAGACAAGAGAGCTCATTGCTAGAAGAACCACACCTCTTTTGGAATATATTAAAAATAGAAAATTAGAAAAGCAGAGAATTCGAGAAGAGAAGCGAGAAGAACGGAGGAGGAGAGAGTTAGAAAAGAAACGTTTGCGGGAAGAGGAAAAAAGAAGAAGAAGAGAAGAAGAAAGATGCAAAAAAAAAGAGACAGATAAACAGAAGAAAATTGCAGAGAAAGAAGTAAGGATTAAGCTTCTTAAGAAACCAGAAAAGGGAGAGGAACCAACCACAGAGAAACCAAAAGAAAGAGGAGAGGAGATTGATACTGGAGGTGGCAAGCAGGAATCCTGTGCCCCCGGTGCAGTCGTAAAAGCCAGGCCCATGGAAGGCTCGCTGGAGGAGCCCCAGGAGACGTCACACAGCGGCAGTGATAAAGAGCACAGGGATGTGGAGAGATCTCAAGAACAAGAATCTGAAGCACAAAGATACCATGTGGATGACGGCAGGAGGCACAGAGCTCACCACGAGCCTGAACGGCTTTCCAGAAGGAGTGAGGATGAGCAGAGATGGGGGAAAGGACCTGGCCAAGACAGAGGGAAGAAGGGGAGCCAGGACAGCGGGGCTCCGGGGGAGGCCATGGAGAGACTGGGAAGAGCGCAGAGGTGTGACGACAGTCCAGCACCCAGAAAAGAGCGACTGGCAAACAAGGACCGGCCAGCCTTGCAGCTGTATGATCCAGGAGCTCGCTTCCGAGCGCGAGAGTGTGGCGGAAACAGGAGGATCTGCAAGGCAGAAGGTTCGGGGACTGGTCCTGAGAAGAGGGAAGAGGCAGAGTGA

翻译后氨基酸参数序列： 点击查看序列

ATGCGCTCGGAAAAGGAGGGGGCCGGAGGCCTTCGGGCGGCCGTTGCCGCGCGGGGCCCGAGCGGGAGGGAGAAGCTGTCGGCCCTAGAAGTGCAGTTCCACCGCGACTCGCAGCAGCAGGAGGCTGAGACGCCGCCAACTTCGTCCTCCGGTTGCGGGGGCGGTGCGGGCAAACCTCGCGAGGAGAAGAGGACGGCCCTGAGCAAGGTGGTCATCCGCCGCCTGCCTCCGGGCCTCACCAAGGAGCAGCTGGAGGAGCAGCTGCGCCCGCTGCCAGCACACGACTACTTCGAGTTCTTCGCCGCCGACCTGAGTCTTTATCCTCATCTCTACTCAAGAGCATACATTAATTTTAGGAATCCTGATGACATCCTTCTTTTTAGAGATCGTTTTGATGGATATATCTTCCTTGACAGCAAAGATCCAGAATATAAGAAGTTTTTAGAAACCTACTGTGTGGAGGAAGAGAAGACCAGTGCCAACCCTGAGACTCTGCTGGGGGAGATGGAGGCGAAGACAAGAGAGCTCATTGCTAGAAGAACCACACCTCTTTTGGAATATATTAAAAATAGAAAATTAGAAAAGCAGAGAATTCGAGAAGAGAAGCGAGAAGAACGGAGGAGGAGAGAGTTAGAAAAGAAACGTTTGCGGGAAGAGGAAAAAAGAAGAAGAAGAGAAGAAGAAAGATGCAAAAAAAAAGAGACAGATAAACAGAAGAAAATTGCAGAGAAAGAAGTAAGGATTAAGCTTCTTAAGAAACCAGAAAAGGGAGAGGAACCAACCACAGAGAAACCAAAAGAAAGAGGAGAGGAGATTGATACTGGAGGTGGCAAGCAGGAATCCTGTGCCCCCGGTGCAGTCGTAAAAGCCAGGCCCATGGAAGGCTCGCTGGAGGAGCCCCAGGAGACGTCACACAGCGGCAGTGATAAAGAGCACAGGGATGTGGAGAGATCTCAAGAACAAGAATCTGAAGCACAAAGATACCATGTGGATGACGGCAGGAGGCACAGAGCTCACCACGAGCCTGAACGGCTTTCCAGAAGGAGTGAGGATGAGCAGAGATGGGGGAAAGGACCTGGCCAAGACAGAGGGAAGAAGGGGAGCCAGGACAGCGGGGCTCCGGGGGAGGCCATGGAGAGACTGGGAAGAGCGCAGAGGTGTGACGACAGTCCAGCACCCAGAAAAGAGCGACTGGCAAACAAGGACCGGCCAGCCTTGCAGCTGTATGATCCAGGAGCTCGCTTCCGAGCGCGAGAGTGTGGCGGAAACAGGAGGATCTGCAAGGCAGAAGGTTCGGGGACTGGTCCTGAGAAGAGGGAAGAGGCAGAGTGA