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- 商品货号：G112858
- accession：NM_033238
- 基因别名：PML
- 基因描述：Homo sapiens promyelocytic leukemia (PML), transcript variant 1, mRNA.
- 载体：pDONR223
- CDS区长度：2649
- 翻译后氨基酸长度：882
- TranscriptVariant：This variant (1) represents the longest transcript, and encodes the longest isoform (1, also known as TRIM19alpha).
- 基因简介：The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
- 规格：10ul 质粒
CDS区参考序列： 点击查看序列翻译后氨基酸参数序列： 点击查看序列
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