• 商品货号：G115580

• accession：NM_006029
• 基因别名：PNMA1
• 基因描述：Homo sapiens paraneoplastic Ma antigen 1 (PNMA1), mRNA.
• 载体：现货载体
• CDS区长度：1062
• 翻译后氨基酸长度：353
• 基因简介：The PNMA1 gene encodes an antineuronal antibody (anti-Ma) present in patients with paraneoplastic neurologic disorders (Dalmau et al., 1999 [PubMed 10050892]). Some paraneoplastic syndromes affecting the nervous system are associated with antibodies that react with neuronal proteins and the causal tumor (onconeuronal antigens) (summarized by Dalmau et al., 1999 [PubMed 10050892]). Several of these antibodies are markers of specific neurologic syndromes associated with distinct types of cancer. The presence of some antibodies is so specific that disorders previously identified by brain biopsy or at autopsy can be diagnosed serologically. The expression of neuronal proteins by the tumor appears to be a crucial step that breaks the immune tolerance for otherwise normal neuronal proteins. The identity of most onconeuronal antigens was established by probing human cDNA expression libraries with serum containing antineuronal antibodies.[supplied by OMIM, May 2010]
• 规格：10ul 质粒

CDS区参考序列： 点击查看序列

ATGGCGATGACACTGTTGGAAGACTGGTGCCGGGGGATGGATGTGAACTCCCAGAGAGCTCTGTTAGTCT
GGGGCATCCCAGTGAACTGTGATGAGGCTGAAATCGAAGAGACCCTCCAGGCTGCGATGCCCCAGGTCTC
CTACCGAATGCTTGGGAGAATGTTCTGGAGGGAAGAAAATGCGAAAGCAGCCTTATTAGAGCTCACTGGC
GCTGTAGATTACGCCGCGATCCCCAGGGAGATGCCGGGCAAAGGAGGGGTCTGGAAAGTGTTATTTAAGC
CCCCAACTTCTGATGCTGAATTTTTAGAAAGATTGCACCTCTTCCTAGCTAGAGAGGGGTGGACCGTGCA
AGATGTTGCCCGTGTCCTTGGGTTTCAGAACCCTACTCCGACCCCGGGCCCAGAGATGCCAGCAGAGATG
CTAAACTATATTTTGGATAATGTTATTCAGCCTCTTGTTGAGTCCATATGGTACAAGAGGCTGACACTTT
TCTCGGGGAGGGACATCCCAGGGCCTGGAGAGGAAACCTTTGATCCCTGGCTGGAGCACACTAATGAGGT
CCTAGAGGAGTGGCAGGTGTCCGATGTAGAAAAGAGGCGGCGGTTGATGGAGAGTCTTAGAGGCCCCGCC
GCTGATGTTATTCGCATCCTTAAGTCCAACAACCCCGCGATAACCACTGCCGAATGCCTGAAGGCGCTTG
AGCAGGTGTTTGGGAGCGTTGAGAGCTCTAGGGATGCCCAGATCAAATTTCTGAACACTTATCAGAACCC
GGGAGAAAAATTGTCTGCTTATGTCATTCGTCTGGAGCCTCTGCTACAGAAGGTGGTAGAGAAGGGGGCC
ATTGATAAAGATAATGTGAACCAGGCCCGCCTAGAGCAGGTCATTGCCGGGGCCAACCACAGCGGGGCCA
TCCGAAGGCAGCTGTGGCTTACCGGGGCTGGGGAAGGGCCAGCCCCAAACCTCTTTCAGTTGCTGGTGCA
GATCCGTGAGGAGGAAGCCAAGGAGGAGGAGGAGGAGGCTGAGGCCACCCTTCTGCAGTTAGGCCTGGAA
GGGCACTTCTGA

翻译后氨基酸参数序列： 点击查看序列

ATGGCGATGACACTGTTGGAAGACTGGTGCCGGGGGATGGATGTGAACTCCCAGAGAGCTCTGTTAGTCT
GGGGCATCCCAGTGAACTGTGATGAGGCTGAAATCGAAGAGACCCTCCAGGCTGCGATGCCCCAGGTCTC
CTACCGAATGCTTGGGAGAATGTTCTGGAGGGAAGAAAATGCGAAAGCAGCCTTATTAGAGCTCACTGGC
GCTGTAGATTACGCCGCGATCCCCAGGGAGATGCCGGGCAAAGGAGGGGTCTGGAAAGTGTTATTTAAGC
CCCCAACTTCTGATGCTGAATTTTTAGAAAGATTGCACCTCTTCCTAGCTAGAGAGGGGTGGACCGTGCA
AGATGTTGCCCGTGTCCTTGGGTTTCAGAACCCTACTCCGACCCCGGGCCCAGAGATGCCAGCAGAGATG
CTAAACTATATTTTGGATAATGTTATTCAGCCTCTTGTTGAGTCCATATGGTACAAGAGGCTGACACTTT
TCTCGGGGAGGGACATCCCAGGGCCTGGAGAGGAAACCTTTGATCCCTGGCTGGAGCACACTAATGAGGT
CCTAGAGGAGTGGCAGGTGTCCGATGTAGAAAAGAGGCGGCGGTTGATGGAGAGTCTTAGAGGCCCCGCC
GCTGATGTTATTCGCATCCTTAAGTCCAACAACCCCGCGATAACCACTGCCGAATGCCTGAAGGCGCTTG
AGCAGGTGTTTGGGAGCGTTGAGAGCTCTAGGGATGCCCAGATCAAATTTCTGAACACTTATCAGAACCC
GGGAGAAAAATTGTCTGCTTATGTCATTCGTCTGGAGCCTCTGCTACAGAAGGTGGTAGAGAAGGGGGCC
ATTGATAAAGATAATGTGAACCAGGCCCGCCTAGAGCAGGTCATTGCCGGGGCCAACCACAGCGGGGCCA
TCCGAAGGCAGCTGTGGCTTACCGGGGCTGGGGAAGGGCCAGCCCCAAACCTCTTTCAGTTGCTGGTGCA
GATCCGTGAGGAGGAAGCCAAGGAGGAGGAGGAGGAGGCTGAGGCCACCCTTCTGCAGTTAGGCCTGGAA
GGGCACTTCTGA