• 商品货号：G119951

• accession：NM_138625
• 基因别名：BCL2L11
• 基因描述：Homo sapiens BCL2-like 11 (apoptosis facilitator) (BCL2L11), transcript variant 5, mRNA.
• 载体：现货载体
• CDS区长度：228
• 翻译后氨基酸长度：75
• TranscriptVariant：This variant (5, also known as Bim-beta3) uses an alternate splice site in the 5' coding region, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
• 基因简介：The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]
• 规格：10ul 质粒

CDS区参考序列： 点击查看序列

ATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGA
GGCCTCCCCAGCTCAGACCTGGGGCCCCTACCTCCCTACAGACAGAGCCACAAGTCTCACTCTGTCACCC
AGGCTGGAGTGCACTGGTGCGATCTTGGCTCACTGCAACCTCCAACTCCCAAGTTCAAGCGGTTCTCCTG
CCTCAGCCTCCCAAGTAG

翻译后氨基酸参数序列： 点击查看序列

ATGGCAAAGCAACCTTCTGATGTAAGTTCTGAGTGTGACCGAGAAGGTAGACAATTGCAGCCTGCGGAGA
GGCCTCCCCAGCTCAGACCTGGGGCCCCTACCTCCCTACAGACAGAGCCACAAGTCTCACTCTGTCACCC
AGGCTGGAGTGCACTGGTGCGATCTTGGCTCACTGCAACCTCCAACTCCCAAGTTCAAGCGGTTCTCCTG
CCTCAGCCTCCCAAGTAG