• 商品货号：F114628

• accession：NM_138413
• 基因别名：HOGA1
• 基因描述：Homo sapiens 4-hydroxy-2-oxoglutarate aldolase 1 (HOGA1), transcript variant 1, mRNA.
• 载体： 现货载体
• CDS区长度：984
• 翻译后氨基酸长度：327
• TranscriptVariant：This variant (1) represents the longer transcript and encodes the longer isoform (1).
• 基因简介：The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16), which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2010]
• 载体信息：自有图片地址
• 规格：10ul 质粒

CDS区参考序列： 点击查看序列

ATGCTGGGTCCCCAAGTCTGGTCTTCTGTGAGGCAGGGGCTAAGCAGGAGCTTGTCCAGGAATGTGGGGGTCTGGGCCTCAGGGGAGGGGAAGAAGGTGGACATTGCGGGTATCTACCCCCCTGTGACCACCCCCTTCACTGCCACTGCAGAGGTGGACTATGGGAAACTGGAGGAGAATCTGCACAAACTGGGCACCTTCCCCTTCCGAGGCTTCGTGGTCCAGGGCTCCAATGGCGAGTTTCCTTTCCTGACCAGCAGTGAGCGCCTCGAGGTGGTGAGCCGTGTGCGCCAGGCCATGCCCAAGAACAGGCTCCTGCTAGCTGGCTCCGGATGCGAGTCCACTCAAGCCACAGTGGAGATGACCGTCAGCATGGCCCAGGTCGGGGCTGACGCGGCCATGGTGGTGACCCCTTGCTACTATCGTGGCCGCATGAGCAGTGCGGCCCTCATTCACCACTACACCAAGGTTGCTGATCTCTCTCCAATCCCTGTGGTGCTGTACAGTGTCCCAGCCAACACAGGGCTGGACCTGCCTGTGGATGCAGTGGTCACGCTTTCCCAGCACCCGAATATTGTGGGCATGAAGGACAGCGGTGGTGATGTGACCAGGATTGGGCTGATTGTTCACAAGACCAGGAAGCAGGATTTTCAGGTGTTGGCTGGATCGGCTGGCTTTCTGATGGCCAGCTATGCCTTGGGAGCTGTGGGGGGCGTCTGCGCCCTGGCCAATGTCCTGGGGGCTCAGGTGTGCCAGCTGGAGCGACTGTGCTGCACGGGGCAATGGGAAGATGCCCAGAAACTGCAGCACCGCCTCATTGAGCCAAACGCTGCGGTGACCCGGCGCTTTGGGATCCCAGGGCTGAAGAAAATCATGGACTGGTTTGGCTACTATGGAGGCCCCTGCCGCGCCCCCTTGCAGGAGCTGAGCCCCGCTGAGGAGGAGGCACTGCGCATGGATTTCACCAGCAACGGCTGGCTCTGA

翻译后氨基酸参数序列： 点击查看序列

ATGCTGGGTCCCCAAGTCTGGTCTTCTGTGAGGCAGGGGCTAAGCAGGAGCTTGTCCAGGAATGTGGGGGTCTGGGCCTCAGGGGAGGGGAAGAAGGTGGACATTGCGGGTATCTACCCCCCTGTGACCACCCCCTTCACTGCCACTGCAGAGGTGGACTATGGGAAACTGGAGGAGAATCTGCACAAACTGGGCACCTTCCCCTTCCGAGGCTTCGTGGTCCAGGGCTCCAATGGCGAGTTTCCTTTCCTGACCAGCAGTGAGCGCCTCGAGGTGGTGAGCCGTGTGCGCCAGGCCATGCCCAAGAACAGGCTCCTGCTAGCTGGCTCCGGATGCGAGTCCACTCAAGCCACAGTGGAGATGACCGTCAGCATGGCCCAGGTCGGGGCTGACGCGGCCATGGTGGTGACCCCTTGCTACTATCGTGGCCGCATGAGCAGTGCGGCCCTCATTCACCACTACACCAAGGTTGCTGATCTCTCTCCAATCCCTGTGGTGCTGTACAGTGTCCCAGCCAACACAGGGCTGGACCTGCCTGTGGATGCAGTGGTCACGCTTTCCCAGCACCCGAATATTGTGGGCATGAAGGACAGCGGTGGTGATGTGACCAGGATTGGGCTGATTGTTCACAAGACCAGGAAGCAGGATTTTCAGGTGTTGGCTGGATCGGCTGGCTTTCTGATGGCCAGCTATGCCTTGGGAGCTGTGGGGGGCGTCTGCGCCCTGGCCAATGTCCTGGGGGCTCAGGTGTGCCAGCTGGAGCGACTGTGCTGCACGGGGCAATGGGAAGATGCCCAGAAACTGCAGCACCGCCTCATTGAGCCAAACGCTGCGGTGACCCGGCGCTTTGGGATCCCAGGGCTGAAGAAAATCATGGACTGGTTTGGCTACTATGGAGGCCCCTGCCGCGCCCCCTTGCAGGAGCTGAGCCCCGCTGAGGAGGAGGCACTGCGCATGGATTTCACCAGCAACGGCTGGCTCTGA