- 商品货号:A12687
- 名称:JNJ-28312141
- 简介:JNJ-28312141 is an orally active CSF1R inhibitor (Colony-stimulating factor-1 receptor, CRF1R) and also a FLT3 inhibitor. CSF1R is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. JNJ-28312141 represents a new agent with potential therapeutic activity in acute myeloid leukemia and in settings where CSF-1-dependent macrophages and osteoclasts contribute to tumor growth and skeletal events.
- CASNO:885692-52-4
- 分子式:C26H32N6O2
- 分子量:460.57
- SMILES:CN(C)CC(=O)N1CCC(CC1)C2=CC(=C(C=C2)NC(=O)C3=NC=C(N3)C#N)C4=CCCCC4
- 保持条件:at -20°C 3 years Powder
- 同名:JNJ 28312141, JNJ28312141
- 纯度:>98%
- 应用:CSF1R inhibitor
- 作用机制:Inhibitor