• 靶点-Target： HDAC3
• MW(Observed)： 49kD
• 宿主物种-Host Species： Mouse
• 修饰-Modification： Unmodified
• 推荐稀释比： WB 1:1000
• 组成： Liquid in PBS containing 50% glycerol， 0.5% BSA and 0.02% sodium azide.
• 纯化工艺： The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
• 储存： -15°C to -25°C/1 year(Do not lower than -25°C)
• 克隆性： Monoclonal
• 免疫原： Purified recombinant human HDAC3 protein fragments expressed in E.coli.
• 特异性： This antibody detects endogenous levels of HDAC3 and does not cross-react with related proteins.
• 基因名称： hdac3
• Organism-1： Human
• 基因ID-1： 8841
• SwissProt-1： O15379
• Organism-2： Mouse
• SwissProt-2： O88895
• 背景： Histones play a critical role in transcriptional regulation， cell cycle progression， and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq， Jul 2008]，
• 细胞定位： Nucleus . Cytoplasm . Cytoplasm， cytosol . Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803). Predominantly expressed in the nucleus in the presence of CCAR2 (PubMed:21030595). .

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