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发货规格 |
1×10⁶ |
别名 |
U-87MG; U-87 MG; U87 MG; U-87-MG; U87-MG; U87MG; U-87; U87; 87 MG; 87MG |
形态 |
上皮细胞样 |
生长特性 |
贴壁 |
培养条件 |
MEM+10%FBS+1%P/S |
冻存条件 |
90%FBS+10%DMSO |
传代方式 |
胰酶消化 |
倍增时间 |
34~39h |
传代比例 |
1:2~1:4 |
换液频率 |
每周2~3次 |
生物安全等级 |
1 |
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种属 |
人源 |
组织来源 |
脑 |
肿瘤类型 |
胶质母细胞瘤 |
供体信息 |
44岁男性日本人 |
背景描述 |
U87MG细胞系由人类胶质母细胞瘤建立,是神经生物学和癌症研究中应用最广泛的细胞模型之一。这些细胞起源于中枢神经系统的恶性肿瘤,表现出多形性胶质母细胞瘤 (GBM) 的许多标志性特征,包括快速增殖、高侵袭性以及显着的遗传和表型异质性。这使得U87MG细胞系(也称为U87细胞)成为探索脑肿瘤的分子和细胞机制以及测试潜在治疗策略的宝贵工具。 |
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同工酶 |
Me-2, 1, PGM3, 1, PGM1, 2, ES-D, 1, AK-1, 1, GLO-1, 1, G6PD, B |
致瘤性 |
Yes, in nude mice inoculated subcutaneously with 107 cells |
核型 |
This is a hypodiploid human cell line with the modal chromosome number of 44 occurring in 48% of cells. The rate of higher ploidy was 5.9%., Twelve markers were common to all cells, including der(1)t(1;3) (p22;q21), der(16)t(1;16) (p22;p12), del(9) (p13) and nine others. The marker der(1) had two copies in most cells. There was only one copy of normal X. N1, N6 and N9 were not found. |