• 名称：GDC-0973 (Cobimetinib)
• 简介：Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases.
• CASNO：934660-93-2
• 分子式：C21H21F3IN3O2
• 分子量：530.1
• SMILES：C1CCN[C@@H](C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O
• 保持条件：at -20°C 3 years Powder
• 同名：XL518, XL 518, XL-518, RG7420
• 纯度：>98%
• 应用：MEK1 inhibitor
• 作用机制：Inhibitor