• 名称：Lifirafenib (BGB-283)
• 简介：Lifirafenib (BGB-283), also known as Beigene-283, potently inhibits RAF family kinases and EGFR activities in biochemical assays with IC50 values of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant.
• CASNO：1446090-79-4
• 分子式：C25H17F3N4O3
• 分子量：478.42
• SMILES：O=C1NC2=NC=CC(OC3=CC=C(O[C@@]4([H])[C@]5([H])[C@@H]4C6=NC7=CC=C(C(F)(F)F)C=C7N6)C5=C3)=C2CC1
• 保持条件：at -20°C 3 years Powder
• 同名：BGB283, Beigene-283, BGB 283, Beigene283
• 纯度：>98%
• 应用：BRAF inhibitor
• 作用机制：Inhibitor